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Nicotine caused significantly reduced yields ofDHT, due to down-regulation of 5?-reductase activity, which was overcome by theantioxidant glutathione indicative of modulation of the pro-oxidant effects of nicotine byGSH. TDP-43 pathology is found in mul-tiple brain areas and in a spectrum of diseases as both aprimary and a secondary pathology, suggesting that ALS isa disease that not only affects the pyramidal motor system,but instead it is a multisystem neurodegenerative TDP-43proteinopathy (Geser et al., 2008).
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